252860

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1293917..1294834 Replicon chromosome
Accession NZ_CP101904
Organism Bacillus velezensis strain Ba-0321

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag NPS25_RS06680 Protein ID WP_007407256.1
Coordinates 1294088..1294834 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag NPS25_RS06675 Protein ID WP_003154807.1
Coordinates 1293917..1294087 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPS25_RS06635 (NPS25_06635) 1289140..1290771 + 1632 WP_015417294.1 pyocin knob domain-containing protein -
NPS25_RS06640 (NPS25_06640) 1290784..1291155 + 372 WP_015417295.1 XkdW family protein -
NPS25_RS06645 (NPS25_06645) 1291160..1291357 + 198 WP_012117366.1 XkdX family protein -
NPS25_RS06650 (NPS25_06650) 1291414..1292175 + 762 WP_031378811.1 hypothetical protein -
NPS25_RS06655 (NPS25_06655) 1292227..1292490 + 264 WP_031378810.1 hemolysin XhlA family protein -
NPS25_RS06660 (NPS25_06660) 1292504..1292767 + 264 WP_003154813.1 phage holin -
NPS25_RS06665 (NPS25_06665) 1292781..1293659 + 879 WP_031378809.1 N-acetylmuramoyl-L-alanine amidase -
NPS25_RS06670 (NPS25_06670) 1293695..1293820 - 126 WP_023356844.1 hypothetical protein -
NPS25_RS06675 (NPS25_06675) 1293917..1294087 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NPS25_RS06680 (NPS25_06680) 1294088..1294834 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NPS25_RS06685 (NPS25_06685) 1294939..1295937 - 999 WP_003154805.1 inorganic phosphate transporter -
NPS25_RS06690 (NPS25_06690) 1295950..1296567 - 618 WP_003154804.1 DUF47 domain-containing protein -
NPS25_RS06695 (NPS25_06695) 1296853..1298169 - 1317 WP_007610842.1 amino acid permease -
NPS25_RS06700 (NPS25_06700) 1298492..1299442 + 951 WP_031378808.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T252860 WP_007407256.1 NZ_CP101904:c1294834-1294088 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT252860 WP_003154807.1 NZ_CP101904:c1294087-1293917 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References