Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 5150858..5152366 Replicon chromosome
Accession NZ_CP101885
Organism Pseudomonas aeruginosa strain M27432

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NOQ96_RS24325 Protein ID WP_073660237.1
Coordinates 5151779..5152366 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag NOQ96_RS24320 Protein ID WP_003091607.1
Coordinates 5150858..5151712 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ96_RS24305 (NOQ96_24305) 5146277..5146486 + 210 WP_003091604.1 cold-shock protein -
NOQ96_RS24310 (NOQ96_24310) 5146547..5148421 - 1875 WP_003091605.1 MFS transporter -
NOQ96_RS24315 (NOQ96_24315) 5148596..5150761 - 2166 WP_003091606.1 TonB-dependent receptor family protein -
NOQ96_RS24320 (NOQ96_24320) 5150858..5151712 - 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
NOQ96_RS24325 (NOQ96_24325) 5151779..5152366 - 588 WP_073660237.1 GNAT family protein Toxin
NOQ96_RS24330 (NOQ96_24330) 5152632..5156111 + 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T252858 WP_073660237.1 NZ_CP101885:c5152366-5151779 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLVEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT252858 WP_003091607.1 NZ_CP101885:c5151712-5150858 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References