Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3291198..3292419 Replicon chromosome
Accession NZ_CP101885
Organism Pseudomonas aeruginosa strain M27432

Toxin (Protein)


Gene name vapC Uniprot ID V6AG16
Locus tag NOQ96_RS15825 Protein ID WP_003088107.1
Coordinates 3291198..3291776 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NOQ96_RS15830 Protein ID WP_003088112.1
Coordinates 3291865..3292419 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ96_RS15810 (NOQ96_15810) 3286474..3287751 + 1278 WP_003088104.1 TolC family protein -
NOQ96_RS15815 (NOQ96_15815) 3287741..3289912 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
NOQ96_RS15820 (NOQ96_15820) 3289902..3291089 + 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
NOQ96_RS15825 (NOQ96_15825) 3291198..3291776 - 579 WP_003088107.1 HD domain-containing protein Toxin
NOQ96_RS15830 (NOQ96_15830) 3291865..3292419 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
NOQ96_RS15835 (NOQ96_15835) 3292577..3294772 - 2196 WP_003088114.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
NOQ96_RS15840 (NOQ96_15840) 3294777..3295238 - 462 WP_003088117.1 (2Fe-2S)-binding protein -
NOQ96_RS15845 (NOQ96_15845) 3295569..3295892 + 324 WP_003102734.1 multidrug efflux SMR transporter -
NOQ96_RS15850 (NOQ96_15850) 3295905..3296303 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
NOQ96_RS15855 (NOQ96_15855) 3296300..3296851 - 552 WP_023098678.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-187)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21885.74 Da        Isoelectric Point: 5.3655

>T252857 WP_003088107.1 NZ_CP101885:c3291776-3291198 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT252857 WP_003088112.1 NZ_CP101885:c3292419-3291865 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AG16

Antitoxin

Source ID Structure

References