Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1771..2318 Replicon plasmid p3
Accession NZ_CP101880
Organism Klebsiella pneumoniae strain KPA1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NNX43_RS26915 Protein ID WP_251301932.1
Coordinates 2040..2318 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6G9U792
Locus tag NNX43_RS26910 Protein ID WP_000079935.1
Coordinates 1771..2040 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNX43_RS26905 (1) 1..858 + 858 WP_016240488.1 incFII family plasmid replication initiator RepA -
NNX43_RS26910 (1771) 1771..2040 + 270 WP_000079935.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
NNX43_RS26915 (2040) 2040..2318 + 279 WP_251301932.1 type II toxin-antitoxin system toxin YacB Toxin
NNX43_RS26920 (2364) 2364..3212 + 849 WP_001058003.1 3'-5' exonuclease -
NNX43_RS26925 (3329) 3329..3811 + 483 WP_001311056.1 hypothetical protein -
NNX43_RS26930 (4171) 4171..5287 - 1117 Protein_5 IS91 family transposase -
NNX43_RS26935 (5287) 5287..5652 - 366 WP_000124093.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaOXA-48 - 1..68908 68908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10772.40 Da        Isoelectric Point: 8.4615

>T252848 WP_251301932.1 NZ_CP101880:2040-2318 [Klebsiella pneumoniae]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASSLVGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10198.53 Da        Isoelectric Point: 8.8735

>AT252848 WP_000079935.1 NZ_CP101880:1771-2040 [Klebsiella pneumoniae]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLTHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G9U792

References