Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 90109..90752 Replicon plasmid p1
Accession NZ_CP101878
Organism Klebsiella pneumoniae strain KPA1

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag NNX43_RS26310 Protein ID WP_001044768.1
Coordinates 90336..90752 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag NNX43_RS26305 Protein ID WP_001261287.1
Coordinates 90109..90339 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNX43_RS26295 (85287) 85287..86420 - 1134 WP_000545983.1 DUF3800 domain-containing protein -
NNX43_RS26300 (86683) 86683..89802 - 3120 WP_001553851.1 hypothetical protein -
NNX43_RS26305 (90109) 90109..90339 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NNX43_RS26310 (90336) 90336..90752 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
NNX43_RS26315 (90914) 90914..93052 - 2139 WP_000350635.1 AAA family ATPase -
NNX43_RS26320 (93517) 93517..94512 + 996 WP_000246636.1 hypothetical protein -
NNX43_RS26325 (94555) 94555..95448 + 894 WP_001553853.1 S-4TM family putative pore-forming effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(B) / dfrA12 / aadA2 / qacE / sul1 - 1..111444 111444


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T252846 WP_001044768.1 NZ_CP101878:90336-90752 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT252846 WP_001261287.1 NZ_CP101878:90109-90339 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References