Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5192862..5193487 Replicon chromosome
Accession NZ_CP101877
Organism Klebsiella pneumoniae strain KPA1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NNX43_RS25390 Protein ID WP_040182550.1
Coordinates 5192862..5193245 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NNX43_RS25395 Protein ID WP_004150355.1
Coordinates 5193245..5193487 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNX43_RS25375 (5190228) 5190228..5191130 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NNX43_RS25380 (5191127) 5191127..5191762 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NNX43_RS25385 (5191759) 5191759..5192688 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NNX43_RS25390 (5192862) 5192862..5193245 - 384 WP_040182550.1 type II toxin-antitoxin system VapC family toxin Toxin
NNX43_RS25395 (5193245) 5193245..5193487 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NNX43_RS25400 (5193692) 5193692..5194609 + 918 WP_023302328.1 alpha/beta hydrolase -
NNX43_RS25405 (5194623) 5194623..5195564 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NNX43_RS25410 (5195609) 5195609..5196046 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NNX43_RS25415 (5196043) 5196043..5196903 - 861 WP_004146232.1 virulence factor BrkB family protein -
NNX43_RS25420 (5196897) 5196897..5197496 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14376.67 Da        Isoelectric Point: 9.5352

>T252843 WP_040182550.1 NZ_CP101877:c5193245-5192862 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLKLITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT252843 WP_004150355.1 NZ_CP101877:c5193487-5193245 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References