Detailed information of TA system TA252842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4874486..4876167
• Replicon: chromosome
• Accession: NZ_CP101877
• Organism: Klebsiella pneumoniae strain KPA1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: NNX43_RS23935
• Protein ID: WP_004146663.1
• Coordinates: 4874486..4875403 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: NNX43_RS23940
• Protein ID: WP_004177809.1
• Coordinates: 4875409..4876167 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NNX43_RS23915 (4869792)	4869792..4871312	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
NNX43_RS23920 (4871309)	4871309..4872307	+	999	WP_012737175.1	ribose ABC transporter permease	-
NNX43_RS23925 (4872338)	4872338..4873279	+	942	WP_032417723.1	ABC transporter substrate-binding protein	-
NNX43_RS23930 (4873354)	4873354..4874361	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
NNX43_RS23935 (4874486)	4874486..4875403	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NNX43_RS23940 (4875409)	4875409..4876167	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NNX43_RS23945 (4876253)	4876253..4876981	-	729	WP_004177810.1	response regulator transcription factor	-
NNX43_RS23950 (4877254)	4877254..4879401	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
NNX43_RS23955 (4879631)	4879631..4880317	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T252842 WP_004146663.1 NZ_CP101877:c4875403-4874486 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT252842 WP_004177809.1 NZ_CP101877:c4876167-4875409 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05