Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4714897..4715413 Replicon chromosome
Accession NZ_CP101877
Organism Klebsiella pneumoniae strain KPA1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NNX43_RS23135 Protein ID WP_002886902.1
Coordinates 4714897..4715181 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NNX43_RS23140 Protein ID WP_002886901.1
Coordinates 4715171..4715413 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNX43_RS23110 (4710313) 4710313..4710576 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NNX43_RS23115 (4710706) 4710706..4710879 + 174 WP_032410138.1 hypothetical protein -
NNX43_RS23120 (4710882) 4710882..4711625 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
NNX43_RS23125 (4711982) 4711982..4714120 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NNX43_RS23130 (4714429) 4714429..4714893 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NNX43_RS23135 (4714897) 4714897..4715181 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NNX43_RS23140 (4715171) 4715171..4715413 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NNX43_RS23145 (4715491) 4715491..4717401 - 1911 WP_009486549.1 PRD domain-containing protein -
NNX43_RS23150 (4717424) 4717424..4718578 - 1155 WP_023302389.1 lactonase family protein -
NNX43_RS23155 (4718645) 4718645..4719385 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T252841 WP_002886902.1 NZ_CP101877:c4715181-4714897 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT252841 WP_002886901.1 NZ_CP101877:c4715413-4715171 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References