Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4629613..4630423 Replicon chromosome
Accession NZ_CP101877
Organism Klebsiella pneumoniae strain KPA1

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag NNX43_RS22755 Protein ID WP_014908042.1
Coordinates 4629613..4630146 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag NNX43_RS22760 Protein ID WP_023343051.1
Coordinates 4630157..4630423 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNX43_RS22750 (4628444) 4628444..4629565 + 1122 WP_012737335.1 cupin domain-containing protein -
NNX43_RS22755 (4629613) 4629613..4630146 - 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
NNX43_RS22760 (4630157) 4630157..4630423 - 267 WP_023343051.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NNX43_RS22765 (4630526) 4630526..4631959 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
NNX43_RS22770 (4631949) 4631949..4632632 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NNX43_RS22775 (4632805) 4632805..4634190 + 1386 WP_040182471.1 efflux transporter outer membrane subunit -
NNX43_RS22780 (4634208) 4634208..4634552 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T252840 WP_014908042.1 NZ_CP101877:c4630146-4629613 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT252840 WP_023343051.1 NZ_CP101877:c4630423-4630157 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References