Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2618971..2620559 Replicon chromosome
Accession NZ_CP101877
Organism Klebsiella pneumoniae strain KPA1

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag NNX43_RS12875 Protein ID WP_023301940.1
Coordinates 2618971..2620293 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NNX43_RS12880 Protein ID WP_002904790.1
Coordinates 2620293..2620559 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NNX43_RS12860 (2614027) 2614027..2616528 + 2502 WP_040182042.1 fimbria/pilus outer membrane usher protein -
NNX43_RS12865 (2616516) 2616516..2617520 + 1005 WP_009308876.1 fimbrial protein -
NNX43_RS12870 (2617662) 2617662..2618954 + 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
NNX43_RS12875 (2618971) 2618971..2620293 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
NNX43_RS12880 (2620293) 2620293..2620559 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NNX43_RS12885 (2620825) 2620825..2621151 - 327 WP_004143476.1 hydroxyisourate hydrolase -
NNX43_RS12890 (2621148) 2621148..2621648 - 501 WP_040182039.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NNX43_RS12895 (2621626) 2621626..2623005 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
NNX43_RS12900 (2623351) 2623351..2624505 + 1155 WP_040182036.1 FAD-dependent urate hydroxylase HpxO -
NNX43_RS12905 (2624486) 2624486..2625409 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T252838 WP_023301940.1 NZ_CP101877:c2620293-2618971 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT252838 WP_002904790.1 NZ_CP101877:c2620559-2620293 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References