Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4018519..4019114 Replicon chromosome
Accession NZ_CP101866
Organism Escherichia coli strain LP5-1

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag NPX81_RS19630 Protein ID WP_112934936.1
Coordinates 4018764..4019114 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NPX81_RS19625 Protein ID WP_001223208.1
Coordinates 4018519..4018770 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX81_RS19615 (4014184) 4014184..4017963 + 3780 WP_089619462.1 autotransporter assembly complex protein TamB -
NPX81_RS19620 (4017966) 4017966..4018307 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NPX81_RS19625 (4018519) 4018519..4018770 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NPX81_RS19630 (4018764) 4018764..4019114 + 351 WP_112934936.1 endoribonuclease toxin ChpB Toxin
NPX81_RS19635 (4019191) 4019191..4019721 - 531 WP_000055070.1 inorganic diphosphatase -
NPX81_RS19640 (4020031) 4020031..4020987 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NPX81_RS19645 (4021127) 4021127..4022629 + 1503 WP_000205807.1 sugar ABC transporter ATP-binding protein -
NPX81_RS19650 (4022643) 4022643..4023665 + 1023 WP_053292440.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-115)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12526.42 Da        Isoelectric Point: 5.6219

>T252822 WP_112934936.1 NZ_CP101866:4018764-4019114 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARQAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT252822 WP_001223208.1 NZ_CP101866:4018519-4018770 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References