Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3814159..3814709 Replicon chromosome
Accession NZ_CP101866
Organism Escherichia coli strain LP5-1

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag NPX81_RS18595 Protein ID WP_001160975.1
Coordinates 3814159..3814473 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag NPX81_RS18600 Protein ID WP_000125566.1
Coordinates 3814476..3814709 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX81_RS18570 (3809834) 3809834..3811120 + 1287 WP_032222109.1 peptidylprolyl isomerase SurA -
NPX81_RS18575 (3811120) 3811120..3812109 + 990 WP_044189225.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
NPX81_RS18580 (3812106) 3812106..3812927 + 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NPX81_RS18585 (3812930) 3812930..3813307 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
NPX81_RS18590 (3813314) 3813314..3814162 + 849 WP_000257188.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
NPX81_RS18595 (3814159) 3814159..3814473 - 315 WP_001160975.1 CcdB family protein Toxin
NPX81_RS18600 (3814476) 3814476..3814709 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NPX81_RS18605 (3814795) 3814795..3815274 - 480 WP_001487721.1 type 3 dihydrofolate reductase -
NPX81_RS18610 (3815466) 3815466..3815930 - 465 Protein_3640 NAD-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3815945..3816448 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T252819 WP_001160975.1 NZ_CP101866:c3814473-3814159 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT252819 WP_000125566.1 NZ_CP101866:c3814709-3814476 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References