Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 993297..993880 Replicon chromosome
Accession NZ_CP101866
Organism Escherichia coli strain LP5-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NPX81_RS04800 Protein ID WP_089601808.1
Coordinates 993545..993880 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A161R357
Locus tag NPX81_RS04795 Protein ID WP_040062758.1
Coordinates 993297..993545 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX81_RS04785 (989636) 989636..990937 + 1302 WP_040062759.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
NPX81_RS04790 (990985) 990985..993219 + 2235 WP_000226815.1 GTP pyrophosphokinase -
NPX81_RS04795 (993297) 993297..993545 + 249 WP_040062758.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NPX81_RS04800 (993545) 993545..993880 + 336 WP_089601808.1 endoribonuclease MazF Toxin
NPX81_RS04805 (993951) 993951..994742 + 792 WP_001071643.1 nucleoside triphosphate pyrophosphohydrolase -
NPX81_RS04810 (994970) 994970..996607 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
NPX81_RS04815 (996695) 996695..997993 + 1299 WP_000036723.1 phosphopyruvate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

Antitoxin PemI-like

(2-82)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12142.09 Da        Isoelectric Point: 8.2618

>T252807 WP_089601808.1 NZ_CP101866:993545-993880 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKSSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTLAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9297.70 Da        Isoelectric Point: 4.5972

>AT252807 WP_040062758.1 NZ_CP101866:993297-993545 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNGITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A161R357

References