Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 853955..854609 Replicon chromosome
Accession NZ_CP101866
Organism Escherichia coli strain LP5-1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NPX81_RS04205 Protein ID WP_000244777.1
Coordinates 854202..854609 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NPX81_RS04200 Protein ID WP_000354046.1
Coordinates 853955..854221 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX81_RS04175 (849124) 849124..849867 + 744 WP_000951948.1 SDR family oxidoreductase -
NPX81_RS04180 (849924) 849924..851357 - 1434 WP_040062540.1 6-phospho-beta-glucosidase BglA -
NPX81_RS04185 (851402) 851402..851713 + 312 WP_001182947.1 N(4)-acetylcytidine aminohydrolase -
NPX81_RS04190 (851877) 851877..852536 + 660 WP_000250274.1 hemolysin III family protein -
NPX81_RS04195 (852732) 852732..853712 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NPX81_RS04200 (853955) 853955..854221 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NPX81_RS04205 (854202) 854202..854609 + 408 WP_000244777.1 protein YgfX Toxin
NPX81_RS04210 (854649) 854649..855170 - 522 WP_001055874.1 flavodoxin FldB -
NPX81_RS04215 (855282) 855282..856178 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NPX81_RS04220 (856203) 856203..856913 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NPX81_RS04225 (856919) 856919..858652 + 1734 WP_180512836.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T252806 WP_000244777.1 NZ_CP101866:854202-854609 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT252806 WP_000354046.1 NZ_CP101866:853955-854221 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References