Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 690203..691044 Replicon chromosome
Accession NZ_CP101866
Organism Escherichia coli strain LP5-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag NPX81_RS03360 Protein ID WP_000854822.1
Coordinates 690661..691044 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0CWL2
Locus tag NPX81_RS03355 Protein ID WP_053271974.1
Coordinates 690203..690571 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX81_RS03335 (687948) 687948..688766 + 819 WP_001234702.1 DUF932 domain-containing protein -
NPX81_RS03340 (688857) 688857..689342 + 486 WP_042631074.1 antirestriction protein -
NPX81_RS03345 (689357) 689357..689833 + 477 WP_001186747.1 RadC family protein -
NPX81_RS03350 (689902) 689902..690123 + 222 WP_000692312.1 DUF987 domain-containing protein -
NPX81_RS03355 (690203) 690203..690571 + 369 WP_053271974.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NPX81_RS03360 (690661) 690661..691044 + 384 WP_000854822.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
NPX81_RS03365 (691035) 691035..691523 + 489 WP_001177592.1 DUF5983 family protein -
NPX81_RS03370 (691535) 691535..691732 + 198 WP_000839263.1 DUF957 domain-containing protein -
NPX81_RS03375 (691829) 691829..692674 + 846 WP_001280435.1 DUF4942 domain-containing protein -
NPX81_RS03385 (692973) 692973..693479 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
NPX81_RS03390 (693558) 693558..695399 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T252805 WP_000854822.1 NZ_CP101866:690661-691044 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13679.41 Da        Isoelectric Point: 6.4758

>AT252805 WP_053271974.1 NZ_CP101866:690203-690571 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CWL2

References