Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 123954..124566 Replicon chromosome
Accession NZ_CP101866
Organism Escherichia coli strain LP5-1

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag NPX81_RS00610 Protein ID WP_000833473.1
Coordinates 123954..124139 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5F1W1Z0
Locus tag NPX81_RS00615 Protein ID WP_000499743.1
Coordinates 124156..124566 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX81_RS00595 (119506) 119506..120657 + 1152 WP_000168699.1 L-threonine dehydrogenase -
NPX81_RS00600 (120822) 120822..122360 + 1539 WP_001359414.1 aldehyde dehydrogenase AldB -
NPX81_RS00605 (122401) 122401..123480 - 1080 WP_170854857.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
NPX81_RS00610 (123954) 123954..124139 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
NPX81_RS00615 (124156) 124156..124566 + 411 WP_000499743.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NPX81_RS00620 (124638) 124638..126602 - 1965 WP_040062336.1 glycoside hydrolase family 127 protein -
NPX81_RS00625 (126613) 126613..128013 - 1401 WP_000204832.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 128321..128824 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T252804 WP_000833473.1 NZ_CP101866:123954-124139 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15213.09 Da        Isoelectric Point: 4.5486

>AT252804 WP_000499743.1 NZ_CP101866:124156-124566 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGA

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1W1Z0

References