252800

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 39732..40233 Replicon plasmid pLP50-1-87kb
Accession NZ_CP101860
Organism Escherichia coli strain LP50-1

Toxin (Protein)


Gene name TsxA Uniprot ID H1ZXU8
Locus tag NPX80_RS24330 Protein ID WP_000702247.1
Coordinates 39732..39992 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag NPX80_RS24335 Protein ID WP_001132407.1
Coordinates 39982..40233 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX80_RS24295 (NPX80_24300) 35127..35411 - 285 WP_001162371.1 hypothetical protein -
NPX80_RS24300 (NPX80_24305) 35485..36150 - 666 WP_000532148.1 division plane positioning ATPase MipZ -
NPX80_RS24305 (NPX80_24310) 36747..37076 + 330 WP_000855120.1 hypothetical protein -
NPX80_RS24310 (NPX80_24315) 37657..37797 + 141 WP_256637695.1 hypothetical protein -
NPX80_RS24315 (NPX80_24320) 37956..39065 - 1110 Protein_37 IS4 family transposase -
NPX80_RS24320 (NPX80_24325) 39150..39359 + 210 WP_000866036.1 hypothetical protein -
NPX80_RS24325 (NPX80_24330) 39456..39680 + 225 WP_000814381.1 hypothetical protein -
NPX80_RS24330 (NPX80_24335) 39732..39992 + 261 WP_000702247.1 hypothetical protein Toxin
NPX80_RS24335 (NPX80_24340) 39982..40233 + 252 WP_001132407.1 transcriptional regulator Antitoxin
NPX80_RS24340 (NPX80_24345) 40783..41061 + 279 WP_000545938.1 hypothetical protein -
NPX80_RS24345 (NPX80_24350) 41481..41747 + 267 WP_000681608.1 type II toxin-antitoxin system HicB family antitoxin -
NPX80_RS24350 (NPX80_24355) 41854..42297 - 444 WP_000068545.1 hypothetical protein -
NPX80_RS24355 (NPX80_24360) 42594..42776 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
NPX80_RS24360 (NPX80_24365) 42801..43238 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
NPX80_RS24365 (NPX80_24370) 43369..43695 - 327 WP_000206697.1 hypothetical protein -
NPX80_RS24370 (NPX80_24375) 43715..44422 - 708 WP_256482667.1 hypothetical protein -
NPX80_RS24375 (NPX80_24380) 44424..45176 - 753 WP_000797966.1 conjugal transfer protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..87554 87554


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-37)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9817.29 Da        Isoelectric Point: 10.0665

>T252800 WP_000702247.1 NZ_CP101860:39732-39992 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9404.77 Da        Isoelectric Point: 9.8120

>AT252800 WP_001132407.1 NZ_CP101860:39982-40233 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1P8DNC0

Antitoxin

Source ID Structure

References