Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4383256..4383874 Replicon chromosome
Accession NZ_CP101858
Organism Escherichia coli strain LP50-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NPX80_RS21175 Protein ID WP_001291435.1
Coordinates 4383256..4383474 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NPX80_RS21180 Protein ID WP_000344800.1
Coordinates 4383500..4383874 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX80_RS21140 (4378545) 4378545..4379117 + 573 WP_000779831.1 YbaY family lipoprotein -
NPX80_RS21145 (4379148) 4379148..4379459 - 312 WP_000409911.1 MGMT family protein -
NPX80_RS21155 (4379838) 4379838..4380191 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NPX80_RS21160 (4380233) 4380233..4381783 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NPX80_RS21165 (4381947) 4381947..4382417 - 471 WP_000136192.1 YlaC family protein -
NPX80_RS21170 (4382533) 4382533..4383084 - 552 WP_000102568.1 maltose O-acetyltransferase -
NPX80_RS21175 (4383256) 4383256..4383474 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NPX80_RS21180 (4383500) 4383500..4383874 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NPX80_RS21185 (4384420) 4384420..4387569 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NPX80_RS21190 (4387592) 4387592..4388785 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T252793 WP_001291435.1 NZ_CP101858:c4383474-4383256 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT252793 WP_000344800.1 NZ_CP101858:c4383874-4383500 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References