Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3639689..3640284 Replicon chromosome
Accession NZ_CP101858
Organism Escherichia coli strain LP50-1

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NPX80_RS17640 Protein ID WP_000239579.1
Coordinates 3639934..3640284 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NPX80_RS17635 Protein ID WP_001223208.1
Coordinates 3639689..3639940 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX80_RS17625 (3635353) 3635353..3639132 + 3780 WP_000060901.1 autotransporter assembly complex protein TamB -
NPX80_RS17630 (3639135) 3639135..3639476 + 342 WP_063100134.1 gamma-glutamylcyclotransferase -
NPX80_RS17635 (3639689) 3639689..3639940 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NPX80_RS17640 (3639934) 3639934..3640284 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NPX80_RS17645 (3640364) 3640364..3640894 - 531 WP_000055072.1 inorganic diphosphatase -
NPX80_RS17650 (3641204) 3641204..3642160 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NPX80_RS17655 (3642470) 3642470..3643972 + 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
NPX80_RS17660 (3643986) 3643986..3645008 + 1023 WP_001339490.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T252790 WP_000239579.1 NZ_CP101858:3639934-3640284 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT252790 WP_001223208.1 NZ_CP101858:3639689-3639940 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References