Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2749797..2750383 Replicon chromosome
Accession NZ_CP101858
Organism Escherichia coli strain LP50-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag NPX80_RS13470 Protein ID WP_042014162.1
Coordinates 2750153..2750383 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NPX80_RS13465 Protein ID WP_000593555.1
Coordinates 2749797..2750156 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX80_RS13440 (2745929) 2745929..2746873 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
NPX80_RS13445 (2746870) 2746870..2747703 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NPX80_RS13450 (2747703) 2747703..2748467 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NPX80_RS13455 (2748464) 2748464..2749270 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NPX80_RS13460 (2749276) 2749276..2749677 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NPX80_RS13465 (2749797) 2749797..2750156 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NPX80_RS13470 (2750153) 2750153..2750383 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
NPX80_RS13475 (2750487) 2750487..2751611 - 1125 WP_001314210.1 ABC transporter permease -
NPX80_RS13480 (2751611) 2751611..2754346 - 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T252787 WP_042014162.1 NZ_CP101858:c2750383-2750153 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT252787 WP_000593555.1 NZ_CP101858:c2750156-2749797 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References