Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2151583..2152237 Replicon chromosome
Accession NZ_CP101858
Organism Escherichia coli strain LP50-1

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag NPX80_RS10450 Protein ID WP_000244772.1
Coordinates 2151583..2151990 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag NPX80_RS10455 Protein ID WP_063100142.1
Coordinates 2151971..2152237 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX80_RS10430 (2147540) 2147540..2149273 - 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -
NPX80_RS10435 (2149279) 2149279..2149989 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NPX80_RS10440 (2150014) 2150014..2150910 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NPX80_RS10445 (2151022) 2151022..2151543 + 522 WP_001055874.1 flavodoxin FldB -
NPX80_RS10450 (2151583) 2151583..2151990 - 408 WP_000244772.1 protein YgfX Toxin
NPX80_RS10455 (2151971) 2151971..2152237 - 267 WP_063100142.1 FAD assembly factor SdhE Antitoxin
NPX80_RS10460 (2152480) 2152480..2153460 + 981 WP_242808472.1 tRNA-modifying protein YgfZ -
NPX80_RS10465 (2153537) 2153537..2154196 - 660 WP_000250274.1 hemolysin III family protein -
NPX80_RS10470 (2154360) 2154360..2154671 - 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
NPX80_RS10475 (2154716) 2154716..2156149 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
NPX80_RS10480 (2156206) 2156206..2156949 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T252784 WP_000244772.1 NZ_CP101858:c2151990-2151583 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10548.07 Da        Isoelectric Point: 5.1599

>AT252784 WP_063100142.1 NZ_CP101858:c2152237-2151971 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFNRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure

References