Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1716285..1716910 Replicon chromosome
Accession NZ_CP101858
Organism Escherichia coli strain LP50-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NPX80_RS08370 Protein ID WP_000911330.1
Coordinates 1716285..1716683 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NPX80_RS08375 Protein ID WP_000450524.1
Coordinates 1716683..1716910 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPX80_RS08350 (1712163) 1712163..1712363 + 201 WP_000383836.1 YpfN family protein -
NPX80_RS08355 (1712473) 1712473..1713171 - 699 WP_000679823.1 esterase -
NPX80_RS08360 (1713245) 1713245..1715260 - 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
NPX80_RS08365 (1715275) 1715275..1716138 - 864 WP_001267508.1 neutral zinc metallopeptidase -
NPX80_RS08370 (1716285) 1716285..1716683 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NPX80_RS08375 (1716683) 1716683..1716910 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NPX80_RS08380 (1717064) 1717064..1717777 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NPX80_RS08385 (1717990) 1717990..1719024 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NPX80_RS08390 (1719041) 1719041..1719919 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NPX80_RS08395 (1720065) 1720065..1720637 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NPX80_RS08400 (1720637) 1720637..1721107 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T252782 WP_000911330.1 NZ_CP101858:c1716683-1716285 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT252782 WP_000450524.1 NZ_CP101858:c1716910-1716683 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References