Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1979594..1980080 Replicon chromosome
Accession NZ_CP101844
Organism Streptococcus suis strain 2018WUSS151

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag NOV99_RS09730 Protein ID WP_011922754.1
Coordinates 1979811..1980080 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag NOV99_RS09725 Protein ID WP_002938604.1
Coordinates 1979594..1979821 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV99_RS09700 (NOV99_09700) 1974926..1975471 - 546 WP_002938614.1 NADPH-dependent FMN reductase -
NOV99_RS09705 (NOV99_09705) 1975534..1975983 - 450 WP_002938613.1 MarR family transcriptional regulator -
NOV99_RS09710 (NOV99_09710) 1976286..1976783 + 498 WP_002938611.1 DUF5590 domain-containing protein -
NOV99_RS09715 (NOV99_09715) 1976780..1977961 + 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
NOV99_RS09720 (NOV99_09720) 1977976..1979322 + 1347 WP_013730302.1 asparagine--tRNA ligase -
NOV99_RS09725 (NOV99_09725) 1979594..1979821 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
NOV99_RS09730 (NOV99_09730) 1979811..1980080 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOV99_RS09735 (NOV99_09735) 1980486..1980881 + 396 WP_044667951.1 MATE family efflux transporter -
NOV99_RS09740 (NOV99_09740) 1980947..1982235 + 1289 Protein_1892 IS4-like element ISSsu2 family transposase -
NOV99_RS09745 (NOV99_09745) 1982518..1984513 + 1996 Protein_1893 PTS system trehalose-specific EIIBC component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T252764 WP_011922754.1 NZ_CP101844:1979811-1980080 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT252764 WP_002938604.1 NZ_CP101844:1979594-1979821 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References