Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-couple_hipB |
| Location | 1953769..1955012 | Replicon | chromosome |
| Accession | NZ_CP101844 | ||
| Organism | Streptococcus suis strain 2018WUSS151 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | G7SEB4 |
| Locus tag | NOV99_RS09610 | Protein ID | WP_001235242.1 |
| Coordinates | 1954245..1955012 (+) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | sezA | Uniprot ID | - |
| Locus tag | NOV99_RS09605 | Protein ID | WP_000578719.1 |
| Coordinates | 1953769..1954245 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NOV99_RS09575 (NOV99_09575) | 1948923..1949819 | - | 897 | WP_001809760.1 | ParA family protein | - |
| NOV99_RS09580 (NOV99_09580) | 1949910..1951553 | + | 1644 | WP_004607528.1 | recombinase family protein | - |
| NOV99_RS09585 (NOV99_09585) | 1951617..1952717 | + | 1101 | WP_000196860.1 | toprim domain-containing protein | - |
| NOV99_RS09590 (NOV99_09590) | 1952745..1952972 | + | 228 | WP_000110922.1 | DUF5965 family protein | - |
| NOV99_RS09595 (NOV99_09595) | 1952969..1953358 | + | 390 | WP_000048066.1 | DUF5945 family protein | - |
| NOV99_RS09600 (NOV99_09600) | 1953409..1953699 | + | 291 | WP_000667951.1 | hypothetical protein | - |
| NOV99_RS09605 (NOV99_09605) | 1953769..1954245 | + | 477 | WP_000578719.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| NOV99_RS09610 (NOV99_09610) | 1954245..1955012 | + | 768 | WP_001235242.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| NOV99_RS09615 (NOV99_09615) | 1955013..1957556 | + | 2544 | WP_000601012.1 | AAA family ATPase | - |
| NOV99_RS09620 (NOV99_09620) | 1957894..1958256 | + | 363 | WP_000140674.1 | SAG1252 family conjugative relaxosome accessory protein | - |
| NOV99_RS09625 (NOV99_09625) | 1958259..1958624 | + | 366 | WP_000431640.1 | MobC family plasmid mobilization relaxosome protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(O) / erm(B) | - | 1908422..1970079 | 61657 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 28985.80 Da Isoelectric Point: 5.1126
>T252763 WP_001235242.1 NZ_CP101844:1954245-1955012 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEQLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKEHHDGIVENLVDNLRELESENLFDQIQIYQRDRTCIYDSETAEGSAAEVLQECLFGKWSKVEEEMV
KESELLLKELLEKNK
Download Length: 768 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18266.77 Da Isoelectric Point: 4.6424
>AT252763 WP_000578719.1 NZ_CP101844:1953769-1954245 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYHLTLKVE
VIKERGAAILSKLYRYQDSQDIVFDDESNPWILMSDDLAELINTKIYLVATFDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|