Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4787484..4788000 Replicon chromosome
Accession NZ_CP101835
Organism Klebsiella pneumoniae strain GN4549

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NPH93_RS23570 Protein ID WP_002886902.1
Coordinates 4787484..4787768 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NPH93_RS23575 Protein ID WP_002886901.1
Coordinates 4787758..4788000 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPH93_RS23545 (NPH93_23540) 4782968..4783231 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NPH93_RS23550 (NPH93_23545) 4783361..4783534 + 174 WP_002886906.1 hypothetical protein -
NPH93_RS23555 (NPH93_23550) 4783537..4784280 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NPH93_RS23560 (NPH93_23555) 4784637..4786775 + 2139 WP_042943710.1 anaerobic ribonucleoside-triphosphate reductase -
NPH93_RS23565 (NPH93_23560) 4787016..4787480 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NPH93_RS23570 (NPH93_23565) 4787484..4787768 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPH93_RS23575 (NPH93_23570) 4787758..4788000 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NPH93_RS23580 (NPH93_23575) 4788078..4789988 - 1911 WP_004152270.1 PRD domain-containing protein -
NPH93_RS23585 (NPH93_23580) 4790011..4791165 - 1155 WP_002886900.1 lactonase family protein -
NPH93_RS23590 (NPH93_23585) 4791231..4791971 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T252754 WP_002886902.1 NZ_CP101835:c4787768-4787484 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT252754 WP_002886901.1 NZ_CP101835:c4788000-4787758 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References