Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 904585..905242 Replicon chromosome
Accession NZ_CP101835
Organism Klebsiella pneumoniae strain GN4549

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NPH93_RS04610 Protein ID WP_002916310.1
Coordinates 904832..905242 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NPH93_RS04605 Protein ID WP_002916312.1
Coordinates 904585..904851 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPH93_RS04580 (NPH93_04580) 899741..901174 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NPH93_RS04585 (NPH93_04585) 901293..902021 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NPH93_RS04590 (NPH93_04590) 902071..902382 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NPH93_RS04595 (NPH93_04595) 902546..903205 + 660 WP_002916317.1 hemolysin III family protein -
NPH93_RS04600 (NPH93_04600) 903356..904339 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NPH93_RS04605 (NPH93_04605) 904585..904851 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NPH93_RS04610 (NPH93_04610) 904832..905242 + 411 WP_002916310.1 protein YgfX Toxin
NPH93_RS04615 (NPH93_04615) 905249..905770 - 522 WP_002916308.1 flavodoxin FldB -
NPH93_RS04620 (NPH93_04620) 905871..906767 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NPH93_RS04625 (NPH93_04625) 906790..907503 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NPH93_RS04630 (NPH93_04630) 907509..909242 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T252746 WP_002916310.1 NZ_CP101835:904832-905242 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT252746 WP_002916312.1 NZ_CP101835:904585-904851 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References