Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 68653..69245 Replicon plasmid unnamed
Accession NZ_CP101834
Organism Bacillus pumilus strain NDY-10

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NPA43_RS19050 Protein ID WP_106031820.1
Coordinates 68653..68976 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NPA43_RS19055 Protein ID WP_106031819.1
Coordinates 68976..69245 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPA43_RS19020 (NPA43_19020) 64667..64939 - 273 WP_106031826.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
NPA43_RS19025 (NPA43_19025) 65032..65361 - 330 WP_256499719.1 hypothetical protein -
NPA43_RS19030 (NPA43_19030) 65386..66453 - 1068 WP_256499720.1 hypothetical protein -
NPA43_RS19035 (NPA43_19035) 66573..67142 - 570 WP_106031823.1 hypothetical protein -
NPA43_RS19040 (NPA43_19040) 67129..67560 - 432 WP_106031822.1 hypothetical protein -
NPA43_RS19045 (NPA43_19045) 67825..68463 - 639 WP_142393584.1 hypothetical protein -
NPA43_RS19050 (NPA43_19050) 68653..68976 - 324 WP_106031820.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NPA43_RS19055 (NPA43_19055) 68976..69245 - 270 WP_106031819.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NPA43_RS19060 (NPA43_19060) 69355..69741 - 387 WP_106031818.1 hypothetical protein -
NPA43_RS19065 (NPA43_19065) 69752..70954 - 1203 WP_106031817.1 hypothetical protein -
NPA43_RS19070 (NPA43_19070) 72195..72371 + 177 WP_251181573.1 hypothetical protein -
NPA43_RS19075 (NPA43_19075) 72478..73587 + 1110 WP_106031815.1 tetratricopeptide repeat protein -
NPA43_RS19080 (NPA43_19080) 73805..74191 - 387 WP_106031814.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..85178 85178


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-107)

Antitoxin

SpoVT-AbrB domain

(17-60)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11915.74 Da        Isoelectric Point: 7.1320

>T252742 WP_106031820.1 NZ_CP101834:c68976-68653 [Bacillus pumilus]
MSFDKGDLVYVQFTPQAGHEQAGRRPAIVLSPKNFNEITGFAVVCPITSKKKGYPFEVALPDGLAIQGVILTDQIKSLDW
KARSFQFKDTAPETIITECLDKIHTYL

Download         Length: 324 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9888.36 Da        Isoelectric Point: 5.1489

>AT252742 WP_106031819.1 NZ_CP101834:c69245-68976 [Bacillus pumilus]
MEKRHNEVIKVTTVITKWGNSLGVRIPMNIAKVAELENGSEVELIAEDAGIMIKLKNQKPNLDDLLSKVTAENKHTEINF
GGPEGNEMF

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References