Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 27911..28436 Replicon plasmid unnamed5
Accession NZ_CP101795
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name ccdB Uniprot ID D4HQE7
Locus tag NPJ86_RS28030 Protein ID WP_013023785.1
Coordinates 28131..28436 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag NPJ86_RS28025 Protein ID WP_001568025.1
Coordinates 27911..28129 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS28005 (NPJ86_28005) 23067..23846 + 780 WP_013023780.1 hypothetical protein -
NPJ86_RS28010 (NPJ86_28010) 24053..25645 + 1593 WP_015344964.1 hypothetical protein -
NPJ86_RS28015 (NPJ86_28015) 25679..26806 + 1128 WP_013023782.1 DUF4238 domain-containing protein -
NPJ86_RS28020 (NPJ86_28020) 26803..27093 + 291 WP_013023783.1 hypothetical protein -
NPJ86_RS28025 (NPJ86_28025) 27911..28129 + 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
NPJ86_RS28030 (NPJ86_28030) 28131..28436 + 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB Toxin
NPJ86_RS28035 (NPJ86_28035) 28605..29000 + 396 WP_017899885.1 hypothetical protein -
NPJ86_RS28040 (NPJ86_28040) 29027..29341 + 315 WP_053389906.1 hypothetical protein -
NPJ86_RS28045 (NPJ86_28045) 29352..30368 + 1017 WP_017899884.1 hypothetical protein -
NPJ86_RS28050 (NPJ86_28050) 30566..31360 + 795 WP_004197635.1 site-specific integrase -
NPJ86_RS28055 (NPJ86_28055) 31784..32086 - 303 WP_004197636.1 hypothetical protein -
NPJ86_RS28060 (NPJ86_28060) 32083..32709 - 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / blaTEM-1B - 1..95527 95527


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11615.30 Da        Isoelectric Point: 6.4672

>T252737 WP_013023785.1 NZ_CP101795:28131-28436 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT252737 WP_001568025.1 NZ_CP101795:27911-28129 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References