Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 181995..182746 Replicon plasmid unnamed4
Accession NZ_CP101794
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag NPJ86_RS27685 Protein ID WP_048333033.1
Coordinates 181995..182477 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag NPJ86_RS27690 Protein ID WP_004902250.1
Coordinates 182468..182746 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS27665 (NPJ86_27665) 178394..179041 - 648 WP_014386537.1 EcsC family protein -
NPJ86_RS27670 (NPJ86_27670) 179068..179823 - 756 WP_004902235.1 DUF2971 domain-containing protein -
NPJ86_RS27675 (NPJ86_27675) 179924..180316 - 393 WP_123812462.1 hypothetical protein -
NPJ86_RS27680 (NPJ86_27680) 180421..180960 - 540 WP_004902239.1 hypothetical protein -
NPJ86_RS27685 (NPJ86_27685) 181995..182477 - 483 WP_048333033.1 GNAT family N-acetyltransferase Toxin
NPJ86_RS27690 (NPJ86_27690) 182468..182746 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
NPJ86_RS27695 (NPJ86_27695) 182868..183080 - 213 WP_016946198.1 hypothetical protein -
NPJ86_RS27700 (NPJ86_27700) 183188..183529 - 342 WP_032437747.1 hypothetical protein -
NPJ86_RS27705 (NPJ86_27705) 184434..184748 + 315 WP_023288299.1 hypothetical protein -
NPJ86_RS27710 (NPJ86_27710) 184992..185474 - 483 WP_172694439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA 1..212541 212541


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17708.53 Da        Isoelectric Point: 8.9130

>T252736 WP_048333033.1 NZ_CP101794:c182477-181995 [Klebsiella pneumoniae]
MGMRAPESLMSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT252736 WP_004902250.1 NZ_CP101794:c182746-182468 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References