Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 83455..84365 Replicon plasmid unnamed4
Accession NZ_CP101794
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag NPJ86_RS27140 Protein ID WP_004026354.1
Coordinates 83455..83925 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag NPJ86_RS27145 Protein ID WP_004026357.1
Coordinates 83922..84365 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS27110 (NPJ86_27110) 78738..79136 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
NPJ86_RS27115 (NPJ86_27115) 79473..79967 - 495 WP_004212794.1 thermonuclease family protein -
NPJ86_RS27120 (NPJ86_27120) 80144..80410 + 267 WP_223175074.1 DUF1173 family protein -
NPJ86_RS27125 (NPJ86_27125) 80443..81093 + 651 WP_068893702.1 DUF1173 family protein -
NPJ86_RS27135 (NPJ86_27135) 83210..83407 - 198 WP_126123966.1 hypothetical protein -
NPJ86_RS27140 (NPJ86_27140) 83455..83925 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
NPJ86_RS27145 (NPJ86_27145) 83922..84365 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
NPJ86_RS27150 (NPJ86_27150) 84466..84969 - 504 Protein_91 DUF4113 domain-containing protein -
NPJ86_RS27155 (NPJ86_27155) 85067..85288 - 222 WP_004213643.1 DUF2188 domain-containing protein -
NPJ86_RS27160 (NPJ86_27160) 85469..85588 - 120 Protein_93 Fe3+-citrate ABC transporter substrate-binding protein -
NPJ86_RS27165 (NPJ86_27165) 85663..87789 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
NPJ86_RS27170 (NPJ86_27170) 87876..88829 - 954 Protein_95 fec operon regulator FecR -
NPJ86_RS27175 (NPJ86_27175) 88826..89347 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA 1..212541 212541
- flank IS/Tn - - 82479..82982 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T252734 WP_004026354.1 NZ_CP101794:c83925-83455 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT252734 WP_004026357.1 NZ_CP101794:c84365-83922 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References