Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 46129..46865 Replicon plasmid unnamed4
Accession NZ_CP101794
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag NPJ86_RS26935 Protein ID WP_004098919.1
Coordinates 46383..46865 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7D3T1D0
Locus tag NPJ86_RS26930 Protein ID WP_004213599.1
Coordinates 46129..46395 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS26905 (NPJ86_26905) 41361..41918 + 558 WP_004213590.1 recombinase family protein -
NPJ86_RS26910 (NPJ86_26910) 41921..44890 + 2970 WP_004213592.1 Tn3 family transposase -
NPJ86_RS26915 (NPJ86_26915) 44932..45426 + 495 WP_004213594.1 hypothetical protein -
NPJ86_RS26920 (NPJ86_26920) 45487..45690 + 204 WP_004213596.1 HHA domain-containing protein -
NPJ86_RS26925 (NPJ86_26925) 45704..45934 + 231 WP_004213598.1 hypothetical protein -
NPJ86_RS26930 (NPJ86_26930) 46129..46395 + 267 WP_004213599.1 DUF1778 domain-containing protein Antitoxin
NPJ86_RS26935 (NPJ86_26935) 46383..46865 + 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
NPJ86_RS26940 (NPJ86_26940) 47286..48513 + 1228 Protein_49 IS3 family transposase -
NPJ86_RS26945 (NPJ86_26945) 48509..48904 - 396 Protein_50 IS3 family transposase -
NPJ86_RS26950 (NPJ86_26950) 49079..50101 - 1023 WP_004214536.1 porphobilinogen synthase -
NPJ86_RS26955 (NPJ86_26955) 50165..51511 - 1347 WP_048333011.1 dihydroorotase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA 1..212541 212541
- inside IScluster/Tn - - 41361..48513 7152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T252733 WP_004098919.1 NZ_CP101794:46383-46865 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10151.58 Da        Isoelectric Point: 4.5141

>AT252733 WP_004213599.1 NZ_CP101794:46129-46395 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRVLIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A7D3T1D0

References