Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4865049..4866730 Replicon chromosome
Accession NZ_CP101790
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name mosT Uniprot ID A0A2L0KL13
Locus tag NPJ86_RS23750 Protein ID WP_019704723.1
Coordinates 4865049..4865966 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag NPJ86_RS23755 Protein ID WP_004177809.1
Coordinates 4865972..4866730 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS23730 (NPJ86_23730) 4860621..4862141 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
NPJ86_RS23735 (NPJ86_23735) 4862138..4863136 + 999 WP_002885172.1 ribose ABC transporter permease -
NPJ86_RS23740 (NPJ86_23740) 4863167..4864108 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NPJ86_RS23745 (NPJ86_23745) 4864183..4864974 + 792 Protein_4652 PfkB family carbohydrate kinase -
NPJ86_RS23750 (NPJ86_23750) 4865049..4865966 - 918 WP_019704723.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NPJ86_RS23755 (NPJ86_23755) 4865972..4866730 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NPJ86_RS23760 (NPJ86_23760) 4866816..4867544 - 729 WP_002885152.1 response regulator transcription factor -
NPJ86_RS23765 (NPJ86_23765) 4867817..4869964 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
NPJ86_RS23770 (NPJ86_23770) 4870194..4870880 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34632.07 Da        Isoelectric Point: 5.4707

>T252730 WP_019704723.1 NZ_CP101790:c4865966-4865049 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT252730 WP_004177809.1 NZ_CP101790:c4866730-4865972 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0KL13

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References