Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4696350..4696866 Replicon chromosome
Accession NZ_CP101790
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NPJ86_RS22900 Protein ID WP_040225317.1
Coordinates 4696350..4696634 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NPJ86_RS22905 Protein ID WP_002886901.1
Coordinates 4696624..4696866 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS22875 (NPJ86_22875) 4691822..4692130 - 309 WP_016947038.1 PTS sugar transporter subunit IIB -
NPJ86_RS22880 (NPJ86_22880) 4692215..4692388 + 174 WP_002886906.1 hypothetical protein -
NPJ86_RS22885 (NPJ86_22885) 4692391..4693134 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NPJ86_RS22890 (NPJ86_22890) 4693491..4695629 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
NPJ86_RS22895 (NPJ86_22895) 4695882..4696346 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NPJ86_RS22900 (NPJ86_22900) 4696350..4696634 - 285 WP_040225317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPJ86_RS22905 (NPJ86_22905) 4696624..4696866 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NPJ86_RS22910 (NPJ86_22910) 4696944..4698854 - 1911 WP_009486549.1 PRD domain-containing protein -
NPJ86_RS22915 (NPJ86_22915) 4698877..4700031 - 1155 WP_002886900.1 lactonase family protein -
NPJ86_RS22920 (NPJ86_22920) 4700098..4700838 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11172.02 Da        Isoelectric Point: 10.3787

>T252729 WP_040225317.1 NZ_CP101790:c4696634-4696350 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT252729 WP_002886901.1 NZ_CP101790:c4696866-4696624 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References