Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4599543..4600353 Replicon chromosome
Accession NZ_CP101790
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag NPJ86_RS22435 Protein ID WP_004178461.1
Coordinates 4599543..4600076 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NPJ86_RS22440 Protein ID WP_002887278.1
Coordinates 4600087..4600353 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS22430 (NPJ86_22430) 4598374..4599495 + 1122 WP_012737335.1 cupin domain-containing protein -
NPJ86_RS22435 (NPJ86_22435) 4599543..4600076 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
NPJ86_RS22440 (NPJ86_22440) 4600087..4600353 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NPJ86_RS22445 (NPJ86_22445) 4600456..4601889 - 1434 WP_040183236.1 Cu(+)/Ag(+) sensor histidine kinase -
NPJ86_RS22450 (NPJ86_22450) 4601879..4602562 - 684 WP_032105399.1 copper response regulator transcription factor CusR -
NPJ86_RS22455 (NPJ86_22455) 4602735..4604120 + 1386 WP_073558037.1 efflux transporter outer membrane subunit -
NPJ86_RS22460 (NPJ86_22460) 4604138..4604482 + 345 WP_073558038.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T252728 WP_004178461.1 NZ_CP101790:c4600076-4599543 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT252728 WP_002887278.1 NZ_CP101790:c4600353-4600087 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References