Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 794267..794924 Replicon chromosome
Accession NZ_CP101790
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NPJ86_RS03925 Protein ID WP_002916310.1
Coordinates 794514..794924 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NPJ86_RS03920 Protein ID WP_002916312.1
Coordinates 794267..794533 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS03895 (NPJ86_03895) 789423..790856 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
NPJ86_RS03900 (NPJ86_03900) 790975..791703 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NPJ86_RS03905 (NPJ86_03905) 791753..792064 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NPJ86_RS03910 (NPJ86_03910) 792228..792887 + 660 WP_002916317.1 hemolysin III family protein -
NPJ86_RS03915 (NPJ86_03915) 793038..794021 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
NPJ86_RS03920 (NPJ86_03920) 794267..794533 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NPJ86_RS03925 (NPJ86_03925) 794514..794924 + 411 WP_002916310.1 protein YgfX Toxin
NPJ86_RS03930 (NPJ86_03930) 794931..795452 - 522 WP_004144730.1 flavodoxin FldB -
NPJ86_RS03935 (NPJ86_03935) 795553..796449 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NPJ86_RS03940 (NPJ86_03940) 796472..797185 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NPJ86_RS03945 (NPJ86_03945) 797191..798924 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T252720 WP_002916310.1 NZ_CP101790:794514-794924 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT252720 WP_002916312.1 NZ_CP101790:794267-794533 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References