Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1855..2329 Replicon plasmid unnamed5
Accession NZ_CP101789
Organism Klebsiella pneumoniae strain hvKP841

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag NPJ85_RS29315 Protein ID WP_004197762.1
Coordinates 1855..2121 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag NPJ85_RS29320 Protein ID WP_000879771.1
Coordinates 2105..2329 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ85_RS29300 (NPJ85_29300) 472..798 + 327 WP_050516389.1 hypothetical protein -
NPJ85_RS29305 (NPJ85_29305) 824..1369 + 546 WP_023317533.1 hypothetical protein -
NPJ85_RS29310 (NPJ85_29310) 1435..1785 + 351 WP_004197756.1 hypothetical protein -
NPJ85_RS29315 (NPJ85_29315) 1855..2121 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPJ85_RS29320 (NPJ85_29320) 2105..2329 - 225 WP_000879771.1 DUF6290 family protein Antitoxin
NPJ85_RS29325 (NPJ85_29325) 2996..3208 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
NPJ85_RS29330 (NPJ85_29330) 3215..3724 - 510 WP_032433972.1 MbeB family mobilization protein -
NPJ85_RS29335 (NPJ85_29335) 3759..4193 - 435 Protein_8 relaxase/mobilization nuclease domain-containing protein -
NPJ85_RS29340 (NPJ85_29340) 4402..4746 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
NPJ85_RS29345 (NPJ85_29345) 4736..4912 - 177 WP_004197757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T252717 WP_004197762.1 NZ_CP101789:c2121-1855 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT252717 WP_000879771.1 NZ_CP101789:c2329-2105 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References