252714

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 74803..75713 Replicon plasmid unnamed2
Accession NZ_CP101786
Organism Klebsiella pneumoniae strain hvKP841

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag NPJ85_RS28135 Protein ID WP_004026354.1
Coordinates 74803..75273 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag NPJ85_RS28140 Protein ID WP_004026357.1
Coordinates 75270..75713 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ85_RS28095 (NPJ85_28095) 70119..70433 + 315 WP_011251273.1 hypothetical protein -
NPJ85_RS28100 (NPJ85_28100) 70442..70936 + 495 WP_011251274.1 hypothetical protein -
NPJ85_RS28105 (NPJ85_28105) 70942..71382 + 441 WP_011251275.1 hypothetical protein -
NPJ85_RS28110 (NPJ85_28110) 71807..72763 - 957 WP_011251280.1 DsbA family protein -
NPJ85_RS28115 (NPJ85_28115) 72823..73164 - 342 WP_011251281.1 hypothetical protein -
NPJ85_RS28120 (NPJ85_28120) 73178..73489 - 312 WP_011251282.1 hypothetical protein -
NPJ85_RS28125 (NPJ85_28125) 73506..73955 - 450 WP_011251283.1 thioredoxin fold domain-containing protein -
NPJ85_RS28135 (NPJ85_28135) 74803..75273 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
NPJ85_RS28140 (NPJ85_28140) 75270..75713 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
NPJ85_RS28145 (NPJ85_28145) 75814..76317 - 504 Protein_90 DUF4113 domain-containing protein -
NPJ85_RS28150 (NPJ85_28150) 76523..77503 - 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
NPJ85_RS28155 (NPJ85_28155) 77569..78876 + 1308 Protein_92 FepA family TonB-dependent siderophore receptor -
NPJ85_RS28160 (NPJ85_28160) 78938..79159 + 222 WP_004213615.1 hypothetical protein -
NPJ85_RS28165 (NPJ85_28165) 79503..80465 - 963 WP_004902373.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroN / iucA / iucB / iucC / iucD / iutA / rmpA2 1..190034 190034
- inside IScluster/Tn - iroN 68522..82114 13592


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T252714 WP_004026354.1 NZ_CP101786:c75273-74803 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT252714 WP_004026357.1 NZ_CP101786:c75713-75270 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References