252705

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5032759..5034440 Replicon chromosome
Accession NZ_CP101784
Organism Klebsiella pneumoniae strain hvKP841

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NPJ85_RS24935 Protein ID WP_002885155.1
Coordinates 5032759..5033676 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NPJ85_RS24940 Protein ID WP_004151732.1
Coordinates 5033682..5034440 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ85_RS24915 (NPJ85_24915) 5028065..5029585 + 1521 WP_256554968.1 sugar ABC transporter ATP-binding protein -
NPJ85_RS24920 (NPJ85_24920) 5029582..5030580 + 999 WP_002885172.1 ribose ABC transporter permease -
NPJ85_RS24925 (NPJ85_24925) 5030611..5031552 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NPJ85_RS24930 (NPJ85_24930) 5031627..5032634 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NPJ85_RS24935 (NPJ85_24935) 5032759..5033676 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NPJ85_RS24940 (NPJ85_24940) 5033682..5034440 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NPJ85_RS24945 (NPJ85_24945) 5034526..5035254 - 729 WP_002885152.1 response regulator transcription factor -
NPJ85_RS24950 (NPJ85_24950) 5035527..5037674 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NPJ85_RS24955 (NPJ85_24955) 5037904..5038590 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T252705 WP_002885155.1 NZ_CP101784:c5033676-5032759 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT252705 WP_004151732.1 NZ_CP101784:c5034440-5033682 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References