Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4771976..4772786 Replicon chromosome
Accession NZ_CP101784
Organism Klebsiella pneumoniae strain hvKP841

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NPJ85_RS23630 Protein ID WP_002887280.1
Coordinates 4771976..4772509 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NPJ85_RS23635 Protein ID WP_002887278.1
Coordinates 4772520..4772786 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ85_RS23625 (NPJ85_23625) 4770807..4771928 + 1122 WP_002887282.1 cupin domain-containing protein -
NPJ85_RS23630 (NPJ85_23630) 4771976..4772509 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NPJ85_RS23635 (NPJ85_23635) 4772520..4772786 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NPJ85_RS23640 (NPJ85_23640) 4772889..4774322 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
NPJ85_RS23645 (NPJ85_23645) 4774312..4774995 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NPJ85_RS23650 (NPJ85_23650) 4775167..4776552 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
NPJ85_RS23655 (NPJ85_23655) 4776570..4776914 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T252703 WP_002887280.1 NZ_CP101784:c4772509-4771976 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT252703 WP_002887278.1 NZ_CP101784:c4772786-4772520 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References