Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 882206..882860 | Replicon | chromosome |
Accession | NZ_CP101784 | ||
Organism | Klebsiella pneumoniae strain hvKP841 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | R4YHX2 |
Locus tag | NPJ85_RS04455 | Protein ID | WP_004144731.1 |
Coordinates | 882453..882860 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W8UQ37 |
Locus tag | NPJ85_RS04450 | Protein ID | WP_002916312.1 |
Coordinates | 882206..882472 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NPJ85_RS04425 (NPJ85_04425) | 877362..878795 | - | 1434 | WP_002916322.1 | 6-phospho-beta-glucosidase BglA | - |
NPJ85_RS04430 (NPJ85_04430) | 878914..879642 | - | 729 | WP_002916321.1 | MurR/RpiR family transcriptional regulator | - |
NPJ85_RS04435 (NPJ85_04435) | 879692..880003 | + | 312 | WP_002916319.1 | N(4)-acetylcytidine aminohydrolase | - |
NPJ85_RS04440 (NPJ85_04440) | 880167..880826 | + | 660 | WP_002916317.1 | hemolysin III family protein | - |
NPJ85_RS04445 (NPJ85_04445) | 880977..881960 | - | 984 | WP_002916313.1 | tRNA-modifying protein YgfZ | - |
NPJ85_RS04450 (NPJ85_04450) | 882206..882472 | + | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
NPJ85_RS04455 (NPJ85_04455) | 882453..882860 | + | 408 | WP_004144731.1 | protein YgfX | Toxin |
NPJ85_RS04460 (NPJ85_04460) | 882867..883388 | - | 522 | WP_002916308.1 | flavodoxin FldB | - |
NPJ85_RS04465 (NPJ85_04465) | 883489..884385 | + | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
NPJ85_RS04470 (NPJ85_04470) | 884408..885121 | + | 714 | WP_002916301.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
NPJ85_RS04475 (NPJ85_04475) | 885127..886860 | + | 1734 | WP_004151783.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15936.69 Da Isoelectric Point: 11.4778
>T252695 WP_004144731.1 NZ_CP101784:882453-882860 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
Download Length: 408 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A378E4P6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY41 |