Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4878937..4879453 Replicon chromosome
Accession NZ_CP101776
Organism Klebsiella pneumoniae strain hvKP340

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NPJ84_RS24140 Protein ID WP_002886902.1
Coordinates 4878937..4879221 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NPJ84_RS24145 Protein ID WP_002886901.1
Coordinates 4879211..4879453 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ84_RS24115 (NPJ84_24115) 4874421..4874684 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NPJ84_RS24120 (NPJ84_24120) 4874814..4874987 + 174 WP_002886906.1 hypothetical protein -
NPJ84_RS24125 (NPJ84_24125) 4874990..4875733 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NPJ84_RS24130 (NPJ84_24130) 4876090..4878228 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NPJ84_RS24135 (NPJ84_24135) 4878469..4878933 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NPJ84_RS24140 (NPJ84_24140) 4878937..4879221 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPJ84_RS24145 (NPJ84_24145) 4879211..4879453 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NPJ84_RS24150 (NPJ84_24150) 4879531..4881441 - 1911 WP_004152270.1 PRD domain-containing protein -
NPJ84_RS24155 (NPJ84_24155) 4881464..4882618 - 1155 WP_002886900.1 lactonase family protein -
NPJ84_RS24160 (NPJ84_24160) 4882684..4883424 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T252678 WP_002886902.1 NZ_CP101776:c4879221-4878937 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT252678 WP_002886901.1 NZ_CP101776:c4879453-4879211 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References