Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2744212..2745800 Replicon chromosome
Accession NZ_CP101776
Organism Klebsiella pneumoniae strain hvKP340

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NPJ84_RS13630 Protein ID WP_004199851.1
Coordinates 2744212..2745534 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NPJ84_RS13635 Protein ID WP_002904790.1
Coordinates 2745534..2745800 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ84_RS13615 (NPJ84_13615) 2739277..2741778 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NPJ84_RS13620 (NPJ84_13620) 2741766..2742770 + 1005 WP_004199852.1 fimbrial protein -
NPJ84_RS13625 (NPJ84_13625) 2742903..2744195 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NPJ84_RS13630 (NPJ84_13630) 2744212..2745534 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NPJ84_RS13635 (NPJ84_13635) 2745534..2745800 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NPJ84_RS13640 (NPJ84_13640) 2746066..2746392 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NPJ84_RS13645 (NPJ84_13645) 2746389..2746889 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NPJ84_RS13650 (NPJ84_13650) 2746867..2748246 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
NPJ84_RS13655 (NPJ84_13655) 2748592..2749746 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NPJ84_RS13660 (NPJ84_13660) 2749727..2750650 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T252674 WP_004199851.1 NZ_CP101776:c2745534-2744212 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT252674 WP_002904790.1 NZ_CP101776:c2745800-2745534 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References