Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 513266..513837 Replicon chromosome
Accession NC_015567
Organism Serratia plymuthica AS9

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3YYL5
Locus tag SERAS9_RS02410 Protein ID WP_013811308.1
Coordinates 513562..513837 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag SERAS9_RS02405 Protein ID WP_013811307.1
Coordinates 513266..513553 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS9_RS02380 508968..510053 - 1086 WP_013811302.1 carbon-phosphorus lyase complex subunit PhnI -
SERAS9_RS02385 510053..510634 - 582 WP_013811303.1 phosphonate C-P lyase system protein PhnH -
SERAS9_RS02390 510638..511081 - 444 WP_013811304.1 phosphonate C-P lyase system protein PhnG -
SERAS9_RS02395 511082..511807 - 726 WP_174270197.1 phosphonate metabolism transcriptional regulator PhnF -
SERAS9_RS02400 512102..513160 + 1059 WP_013811306.1 permease -
SERAS9_RS02405 513266..513553 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SERAS9_RS02410 513562..513837 + 276 WP_013811308.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
SERAS9_RS02415 513841..514305 - 465 WP_013811309.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
SERAS9_RS02420 514474..516612 - 2139 WP_013811310.1 anaerobic ribonucleoside-triphosphate reductase -
SERAS9_RS02425 516827..517732 - 906 WP_013811311.1 LysR family transcriptional regulator -
SERAS9_RS02430 517837..518361 + 525 WP_013811312.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10712.50 Da        Isoelectric Point: 9.6236

>T25267 WP_013811308.1 NC_015567:513562-513837 [Serratia plymuthica AS9]
MRIEWDNAALRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLEHPELGKTWHGKARKLLINKASLLLVYIIVDDVIKVF
AIAHQREKFPN

Download         Length: 276 bp

>T25267 NC_015567:513562-513837 [Serratia plymuthica AS9]
ATGCGTATCGAATGGGATAATGCAGCGCTACGGGACAGGGAACGTATTTTTGAGTTTCTTTATATTTTCAATCCACAGGC
GGCAGTGCAGGCTGATAACGAGATAGATAAAGCGGTAAAGCGCCTGCTGGAGCATCCTGAGTTAGGTAAGACCTGGCATG
GGAAGGCGCGTAAGCTGCTTATTAATAAGGCCTCTCTGTTGCTGGTATATATCATCGTCGATGATGTTATTAAGGTTTTC
GCGATTGCTCACCAGCGCGAGAAATTTCCAAACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT25267 WP_013811307.1 NC_015567:513266-513553 [Serratia plymuthica AS9]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp

>AT25267 NC_015567:513266-513553 [Serratia plymuthica AS9]
ATGGAAAGTCGTATCCAGTTTCGCATCGAAGATGAAACCAAGCGTTTGGCGCAAAAGGCCGCTGAAGCTAAAGGGACGAC
ATTAAGTGAAGCCTGTCGCCGCTTGGCGGAGCAAATGGCTGATGAGCAACGGGCAGCGGAAGAGCACGAAAACTGGTTGA
AAGATAAGGTAGATGCAGCTTTTTCCCGTCTGCATGAGGGCAATGCTGTCTACCTTAGCCAACAAGAAGTTGAAGAAAGC
ATGGATGCCTTTAAGGCAAAAATCAGAGCGAAATACGACCGAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3YYL5

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References