Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1696..2276 Replicon plasmid unnamed3
Accession NZ_CP101773
Organism Klebsiella pneumoniae strain hvKP323

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag NO368_RS27475 Protein ID WP_071177730.1
Coordinates 1962..2276 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NO368_RS27470 Protein ID WP_000093040.1
Coordinates 1696..1974 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO368_RS27455 (NO368_27455) 269..514 + 246 WP_032440458.1 hypothetical protein -
NO368_RS27460 (NO368_27460) 788..1159 + 372 WP_001237044.1 cell envelope integrity protein TolA -
NO368_RS27465 (NO368_27465) 1156..1521 + 366 WP_072354022.1 TonB family protein -
NO368_RS27470 (NO368_27470) 1696..1974 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NO368_RS27475 (NO368_27475) 1962..2276 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NO368_RS27480 (NO368_27480) 2440..2868 + 429 WP_001140599.1 hypothetical protein -
NO368_RS27485 (NO368_27485) 2894..3073 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
NO368_RS27490 (NO368_27490) 3100..3630 - 531 WP_071177729.1 hypothetical protein -
NO368_RS27495 (NO368_27495) 3637..4368 - 732 WP_071177728.1 MobC family replication-relaxation protein -
NO368_RS27500 (NO368_27500) 4368..6332 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11970 11970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T252656 WP_071177730.1 NZ_CP101773:1962-2276 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT252656 WP_000093040.1 NZ_CP101773:1696-1974 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References