Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4856664..4857180 Replicon chromosome
Accession NZ_CP101770
Organism Klebsiella pneumoniae strain hvKP323

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NO368_RS24040 Protein ID WP_002886902.1
Coordinates 4856664..4856948 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NO368_RS24045 Protein ID WP_002886901.1
Coordinates 4856938..4857180 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO368_RS24015 (NO368_24015) 4852148..4852411 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NO368_RS24020 (NO368_24020) 4852541..4852714 + 174 WP_002886906.1 hypothetical protein -
NO368_RS24025 (NO368_24025) 4852717..4853460 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NO368_RS24030 (NO368_24030) 4853817..4855955 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NO368_RS24035 (NO368_24035) 4856196..4856660 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NO368_RS24040 (NO368_24040) 4856664..4856948 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NO368_RS24045 (NO368_24045) 4856938..4857180 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NO368_RS24050 (NO368_24050) 4857258..4859168 - 1911 WP_004152270.1 PRD domain-containing protein -
NO368_RS24055 (NO368_24055) 4859191..4860345 - 1155 WP_002886900.1 lactonase family protein -
NO368_RS24060 (NO368_24060) 4860411..4861151 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T252653 WP_002886902.1 NZ_CP101770:c4856948-4856664 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT252653 WP_002886901.1 NZ_CP101770:c4857180-4856938 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References