Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 5043608..5044179 Replicon chromosome
Accession NC_015566
Organism Serratia sp. AS12

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3Z6B8
Locus tag SERAS12_RS23385 Protein ID WP_013814818.1
Coordinates 5043901..5044179 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7U3Z6A2
Locus tag SERAS12_RS23380 Protein ID WP_013814817.1
Coordinates 5043608..5043877 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS12_RS23365 5039822..5041039 - 1218 WP_013814814.1 aspartate aminotransferase family protein -
SERAS12_RS23370 5041171..5041746 - 576 WP_013814815.1 aminodeoxychorismate synthase component II -
SERAS12_RS23375 5041852..5043378 - 1527 WP_013814816.1 DUF853 family protein -
SERAS12_RS23380 5043608..5043877 + 270 WP_013814817.1 hypothetical protein Antitoxin
SERAS12_RS23385 5043901..5044179 + 279 WP_013814818.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SERAS12_RS23390 5044180..5044905 - 726 WP_013814819.1 two-component system response regulator BtsR -
SERAS12_RS23395 5044905..5046590 - 1686 WP_013814820.1 sensor histidine kinase -
SERAS12_RS23400 5046750..5047319 - 570 WP_013814821.1 peptidylprolyl isomerase A -
SERAS12_RS23405 5047675..5048013 + 339 WP_041416656.1 PTS lactose/cellobiose transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10232.82 Da        Isoelectric Point: 8.5141

>T25265 WP_013814818.1 NC_015566:5043901-5044179 [Serratia sp. AS12]
VTLKWTEPAIADRMAIYDYLETKNPAAAIEIDSLISAAATRLSQNPSSGKPGRVPGTREMVIHHSYFLIYELTNGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T25265 NC_015566:5043901-5044179 [Serratia sp. AS12]
GTGACACTCAAGTGGACGGAACCCGCGATTGCCGATCGTATGGCAATTTATGACTACCTGGAAACAAAGAATCCGGCCGC
AGCTATAGAAATTGATAGCTTGATTTCAGCAGCTGCGACACGACTCTCACAAAACCCGTCCAGTGGAAAACCAGGCCGAG
TGCCCGGTACACGTGAAATGGTTATTCATCATTCCTACTTTCTGATTTATGAATTAACCAACGGGTTAATCATTATGCTG
GCCGTAGTTCATGCCCGCCGTCAGTGGCCCGCCAATTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10394.73 Da        Isoelectric Point: 7.0169

>AT25265 WP_013814817.1 NC_015566:5043608-5043877 [Serratia sp. AS12]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVETYF
AERRSKLIR

Download         Length: 270 bp

>AT25265 NC_015566:5043608-5043877 [Serratia sp. AS12]
ATGTCTGAATCTACCGTGGTTATCCGAGTGGATGAGGAATTAAAAATCGCCTTTGCCAGCGCTGCCAAAGCAGCTGATCG
CACCGCATCTCAGTTGCTGCGCGATTTCATGCGTGATTTTGTCAGTCGGCAAACTCATCAGAAAGAGTATGAGCAGTGGC
TGCAGGAAAAAGTGGACTTAAGCCGCAAAGCGCTTAATGAAGGAAAAATCACTGATAATGAAGCAGTTGAGACCTACTTC
GCTGAACGTAGGTCAAAACTGATAAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Z6B8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3Z6A2

References