Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2720305..2721893 Replicon chromosome
Accession NZ_CP101770
Organism Klebsiella pneumoniae strain hvKP323

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NO368_RS13510 Protein ID WP_004199851.1
Coordinates 2720305..2721627 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NO368_RS13515 Protein ID WP_002904790.1
Coordinates 2721627..2721893 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO368_RS13495 (NO368_13495) 2715370..2717871 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NO368_RS13500 (NO368_13500) 2717859..2718863 + 1005 WP_004199852.1 fimbrial protein -
NO368_RS13505 (NO368_13505) 2718996..2720288 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NO368_RS13510 (NO368_13510) 2720305..2721627 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NO368_RS13515 (NO368_13515) 2721627..2721893 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NO368_RS13520 (NO368_13520) 2722159..2722485 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NO368_RS13525 (NO368_13525) 2722482..2722982 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NO368_RS13530 (NO368_13530) 2722960..2724339 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
NO368_RS13535 (NO368_13535) 2724685..2725839 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NO368_RS13540 (NO368_13540) 2725820..2726743 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T252649 WP_004199851.1 NZ_CP101770:c2721627-2720305 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT252649 WP_002904790.1 NZ_CP101770:c2721893-2721627 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References