Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 883406..884060 Replicon chromosome
Accession NZ_CP101770
Organism Klebsiella pneumoniae strain hvKP323

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag NO368_RS04460 Protein ID WP_004144731.1
Coordinates 883653..884060 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NO368_RS04455 Protein ID WP_002916312.1
Coordinates 883406..883672 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO368_RS04430 (NO368_04430) 878562..879995 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NO368_RS04435 (NO368_04435) 880114..880842 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NO368_RS04440 (NO368_04440) 880892..881203 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NO368_RS04445 (NO368_04445) 881367..882026 + 660 WP_002916317.1 hemolysin III family protein -
NO368_RS04450 (NO368_04450) 882177..883160 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NO368_RS04455 (NO368_04455) 883406..883672 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NO368_RS04460 (NO368_04460) 883653..884060 + 408 WP_004144731.1 protein YgfX Toxin
NO368_RS04465 (NO368_04465) 884067..884588 - 522 WP_002916308.1 flavodoxin FldB -
NO368_RS04470 (NO368_04470) 884689..885585 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NO368_RS04475 (NO368_04475) 885608..886321 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NO368_RS04480 (NO368_04480) 886327..888060 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T252644 WP_004144731.1 NZ_CP101770:883653-884060 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT252644 WP_002916312.1 NZ_CP101770:883406-883672 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References