252640

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2125..2599 Replicon plasmid unnamed5
Accession NZ_CP101769
Organism Klebsiella pneumoniae strain hvKP319

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag NPJ83_RS30020 Protein ID WP_004197762.1
Coordinates 2125..2391 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag NPJ83_RS30025 Protein ID WP_000879771.1
Coordinates 2375..2599 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ83_RS30005 (NPJ83_30005) 742..1068 + 327 WP_050516389.1 hypothetical protein -
NPJ83_RS30010 (NPJ83_30010) 1094..1639 + 546 WP_023317533.1 hypothetical protein -
NPJ83_RS30015 (NPJ83_30015) 1705..2055 + 351 WP_004197756.1 hypothetical protein -
NPJ83_RS30020 (NPJ83_30020) 2125..2391 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NPJ83_RS30025 (NPJ83_30025) 2375..2599 - 225 WP_000879771.1 DUF6290 family protein Antitoxin
NPJ83_RS30030 (NPJ83_30030) 3266..3478 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
NPJ83_RS30035 (NPJ83_30035) 3485..3994 - 510 WP_032433972.1 MbeB family mobilization protein -
NPJ83_RS30040 (NPJ83_30040) 4029..4463 - 435 Protein_7 relaxase/mobilization nuclease domain-containing protein -
NPJ83_RS30045 (NPJ83_30045) 4672..5016 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
NPJ83_RS30050 (NPJ83_30050) 5006..5182 - 177 WP_004197757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T252640 WP_004197762.1 NZ_CP101769:c2391-2125 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT252640 WP_000879771.1 NZ_CP101769:c2599-2375 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References