Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4390905..4391574 Replicon chromosome
Accession NC_015566
Organism Serratia sp. AS12

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U3Z5B1
Locus tag SERAS12_RS20510 Protein ID WP_013814381.1
Coordinates 4390905..4391327 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S4YS10
Locus tag SERAS12_RS20515 Protein ID WP_004952428.1
Coordinates 4391308..4391574 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS12_RS20490 4386790..4387308 + 519 WP_004952413.1 flavodoxin FldB -
SERAS12_RS20495 4387346..4388710 - 1365 WP_013814378.1 cell envelope integrity protein CreD -
SERAS12_RS20500 4388795..4390213 - 1419 WP_013814379.1 two-component system sensor histidine kinase CreC -
SERAS12_RS20505 4390210..4390905 - 696 WP_013814380.1 two-component system response regulator CreB -
SERAS12_RS20510 4390905..4391327 - 423 WP_013814381.1 protein YgfX Toxin
SERAS12_RS20515 4391308..4391574 - 267 WP_004952428.1 FAD assembly factor SdhE Antitoxin
SERAS12_RS20520 4391899..4392891 + 993 WP_013814382.1 tRNA-modifying protein YgfZ -
SERAS12_RS20525 4393039..4393716 - 678 WP_004952439.1 hemolysin III family protein -
SERAS12_RS20530 4393907..4394515 + 609 WP_013814383.1 HD domain-containing protein -
SERAS12_RS20535 4394562..4395887 - 1326 WP_013814384.1 MHS family MFS transporter -
SERAS12_RS20540 4395884..4396537 - 654 WP_013814385.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16448.47 Da        Isoelectric Point: 10.6049

>T25264 WP_013814381.1 NC_015566:c4391327-4390905 [Serratia sp. AS12]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLVKQPWMPRYGILLTLQPIQGKKCRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Download         Length: 423 bp

>T25264 NC_015566:c4391327-4390905 [Serratia sp. AS12]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGTTACTTTCGCTGCTGACCCACGGCGTTCTTATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTACGGCCCGATCTGGCTGGTGTTGTTGACGCTGGTGGTATTTGAATGCA
TCCGCAGCCAAAAGCGCATTGCGTCACGGCAGGGCGAGCTGCGTTTGCTGGCGAATAAGCGGTTAAGTTGGCACGGACAG
GAATGGTTGCTGGTAAAGCAACCCTGGATGCCGCGTTACGGCATTTTGCTGACGCTGCAGCCGATACAGGGCAAAAAATG
CCGCCGGCTGTGGTTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGTTGTTGCTGCACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10446.90 Da        Isoelectric Point: 5.0843

>AT25264 WP_004952428.1 NC_015566:c4391574-4391308 [Serratia sp. AS12]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT25264 NC_015566:c4391574-4391308 [Serratia sp. AS12]
ATGGATATTAATAATAAAGCACGTATTCACTGGGCCTGCCGCCGTGGCATGCGTGAGCTGGACATCTCAATCATGCCGTT
CTTCGAGCATGAGTACGATCAGTTGAATGACACAGACAAAGCGTTGTTTATCCGCCTGCTTGAGAGCGACGATCCCGATC
TGTTCAACTGGTTGATGAATCATGGCGCTCCGCAAGACAGTGAACTGCAGAGAATGGTGACACTGATCCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Z5B1

Antitoxin

Source ID Structure
AlphaFold DB S4YS10

References